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Barbara Ardelt Selected Research

ranpirnase (Pannon)

7/2014Cytotoxic activity of the amphibian ribonucleases onconase and r-amphinase on tumor cells from B cell lymphoproliferative disorders.
12/2009Ribonucleases as potential modalities in anticancer therapy.
10/2008The cytotoxic ribonuclease onconase targets RNA interference (siRNA).
7/2008Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines.
12/2007Cytostatic and cytotoxic properties of Amphinase: a novel cytotoxic ribonuclease from Rana pipiens oocytes.
4/2007Mild hyperthermia predisposes tumor cells to undergo apoptosis upon treatment with onconase.
12/2004Treatment of Jurkat acute T-lymphocytic leukemia cells by onconase (Ranpirnase) is accompanied by an altered nucleocytoplasmic distribution and reduced expression of transcription factor NF-kappaB.
10/2002Detection of in situ activation of transglutaminase during apoptosis: correlation with the cell cycle phase by multiparameter flow and laser scanning cytometry.
8/2002Activation of caspases and serine proteases during apoptosis induced by onconase (Ranpirnase).

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Barbara Ardelt Research Topics

Disease

8Neoplasms (Cancer)
07/2014 - 02/2002
4Malignant Mesothelioma
10/2008 - 04/2007
2Hyperthermia
04/2007 - 10/2002
1Lymphoproliferative Disorders (Lymphoproliferative Disorder)
07/2014
1Adenocarcinoma of Lung
10/2008
1Leukemia
12/2007
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
12/2004
1Mesothelioma
12/2004

Drug/Important Bio-Agent (IBA)

9ranpirnase (Pannon)IBA
07/2014 - 08/2002
8Ribonucleases (Ribonuclease)IBA
07/2014 - 08/2002
4Cytostatic AgentsIBA
10/2008 - 08/2002
1EnzymesIBA
12/2009
1Oxidoreductases (Dehydrogenase)IBA
10/2008
1MicroRNAs (MicroRNA)IBA
10/2008
1Small Interfering RNA (siRNA)IBA
10/2008
1Glyceraldehyde 3-Phosphate (Glyceraldehyde 3 Phosphate)IBA
10/2008
1Cytotoxins (Cytolysins)IBA
10/2008
1NF-kappa B (NF-kB)IBA
12/2004
1Transcription Factors (Transcription Factor)IBA
12/2004
1CamptothecinIBA
10/2002
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2002
1XanthinesIBA
02/2002
1Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA
02/2002
1Caffeine (No Doz)FDA LinkGeneric
02/2002

Therapy/Procedure

2Drug Therapy (Chemotherapy)
12/2009 - 10/2008
1Radiotherapy
12/2009
1Therapeutics
10/2008